Europa League winners Sevilla, who have been a thorn in the side of English clubs in Europe, contained Chelsea's attacking threats in a game of few clear chances.
Chelsea's most productive spell came after the restart when Kurt Zouma and Ben Chilwell both headed good chances straight at Sevilla keeper Yassine Bounou.
Yet it was a night of defensive superiority as Chelsea manager Frank Lampard experienced his first 0-0 draw since taking over before the start of last season.
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How to watch
TV channel: The match will be televised on BT Sport 3, with coverage starting from 19:15pm.
Chelsea XI: Mendy, James, Thiago Silva, Zouma, Chilwell, Kante, Mount, Jorginho, Pulisic, Havertz, Werner
Subs: Kepa, Caballero, Rudiger, Christensen, Abraham, Tomori, Kovacic, Giroud, Hudson-Odoi, Ziyech, Azpilicueta, Emerson