Victoria has recorded 2,189 new Covid-19 cases on Friday, as all regions in the state came out of lockdown at midnight.
There were also 16 Covid-related deaths reported this morning in the health department's latest update.
It's the deadliest day yet for Victoria's current Delta outbreak and lifts the toll from the current outbreak to 203.
There are currently 784 people in hospital with the virus, including 145 people in the ICU, including 94 on a ventilator.
"We thank everyone who got vaccinated and tested yesterday," The Victorian Department of Health said on Twitter.
"Our thoughts are with those in hospital, and the families of people who have lost their lives."
Cheering broke out from apartment buildings and in the streets as Melbourne's sixth lockdown ended at midnight.
The lockdown lifted in Melbourne after 70 per cent of people aged over 16 were fully vaccinated against Covid-19.
From Friday, people can leave their homes for any reason and travel anywhere within metropolitan Melbourne.
The curfew has been scrapped, home gatherings of up to 10 are allowed, and hairdressers, beauticians and hospitality businesses can reopen for the fully vaccinated with limits.
Mildura also came out of lockdown one day early on Thursday.
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