50 Cent reveals Beyonce run-in

50 Cent. Picture: Supplied

50 Cent claims Beyonce Knowles once confronted him for getting into an argument with Jay Z.

The hitmaker was shocked when Beyonce leaped up to defend her husband at the Cosmopolitan Hotel in Las Vegas.

"One time [Beyoncé] jumped off of a ledge and came running over cause she thought me and Jay had issues. And I'm like, 'What the f**k? Did she really just jump and run up on me like that?'," 50 Cent, real name Curtis Jackson, said.

Beyonce reportedly became very protective of Jay because she thought things were about to turn physical between him and the rapper, but they soon laughed off the dispute.

"She jumped out and I was like this, 'What?! That Bonnie and Clyde for real! You try this or what, boy?! I'm here!' She bugged out at me. I looked and Jay starts laughing. He's like, 'Yo, you know what it is,'" 50 Cent said.

News of Beyonce's run-in with 50 Cent comes almost one month after her sister, Solange Knowles, attacked Jay in an elevator at the Met Ball after party in New York City on May 5.

The trio released a joint statement after video footage of the altercation was leaked, saying: "Jay and Solange each assume their share of responsibility for what has occurred. They both acknowledge their role in this private matter that has played out in the public. They both have apologised to each other and we have moved forward as a united family."