Tumour-shrinking cancer drug approved in US
A small but significant new study is blowing experts away after it found that a particular cancer drug overwhelmingly helped shrink or eradicate tumours in patients whose cancer had resisted every other form of treatment.
The study, which was published in the journal Science, followed 86 patients who had advanced cancer of the pancreas, prostate, uterus, or bone.
The patients were given pembrolizumab, which also goes by the brand name Keytruda, and the results were very promising.
Sixty-six patients had tumors that shrank significantly and stabilized, among them 18 patients whose tumours disappeared and haven’t returned.
The patients all carried genetic mutations that kept their cells from fixing damaged DNA.
Pembrolizumab is known as a PD-1 blocker, an emerging type of immunotherapy drug that helps the immune system find cancer cells and attack tumours.
The study was small, and there was no control group (i.e., a group that didn’t receive pembrolizumab that scientists could compare results against), but the results were so striking that the US Food and Drug Administration, or FDA, has already approved pembrolizumab for patients whose cancer comes from this particular genetic abnormality.
According to the New York Times, this is the first time a drug has been approved for use against tumours that share a particular genetic profile, regardless of where they appear in the body.
Dr Jack Jacoub, a medical oncologist and director of thoracic oncology at MemorialCare Cancer Institute at Orange Coast Memorial Medical Center in Fountain Valley, California, told Yahoo Beauty that the study was “interesting, welcomed, and exciting."
There has been a general opinion that the immune system is integral in the development and spread of cancer and these new findings show that targeting the immune system to treat cancer can be effective.
“To finally see now proof that targeting the immune system improves the situation and doesn’t necessarily correlate with one specific cancer … that’s a really powerful message,” Dr Jacoub said.
Dr Jacoub also points out that the FDA’s move to approve pembrolizumab quickly was a big step.
“The FDA doesn’t take these kinds of things lightly,” he said. “The data was so good, they had to approve it.”
Dr Jacoub says he suspects that drugs like this will be used in the future in connection with more established cancer treatments for specific types of the disease.
“This may improve outcomes,” he said.
“This form of therapy, plus something else, may allow us to potentially cure and eradicate cancer. These are the steps that are getting us closer to that goal.”
