The Hammers were unlucky to come away from the Emirates without a point last week, and though defeating Hull in the Carabao Cup on Tuesday, they were dealt a blow with David Moyes, Issa Diop and Josh Cullen testing positive for coronavirus ahead of that match.
Assistant manager Alan Irvine has confirmed Moyes will still be in charge this weekend - although from the comfort of his own home.
They come up against a Wolves side with one league win from two after falling marginally short against Manchester City last time out.
Date, time and venue
West Ham vs Wolves is scheduled for a 7pm BST kick-off on Sunday, September 27.
This match will be played behind closed doors at London Stadium with no fans due to be present due to government guidelines regarding coronavirus.
How to watch
TV channel: The match will be televised on BT Sport 1, with coverage starting from 6.30pm.
Having tested positive for coronavirus, manager David Moyes and players Issa Diop and Josh Cullen are self-isolating for 10 days and will therefore be absent against Wolves.
Though yet to win in the league so far, West Ham put in an encouraging performance against Arsenal last weekend.
Consequently, Moyes - managing the game from home - will likely field a near-identical side, though of course Diop will need to be replaced.
Captain Mark Noble may also return to the side, having returned to training after missing the last two games with a toe injury.
West Ham XI to face Wolves (5-4-1): Fabianski; Fredericks, Balbuena, Ogbonna, Cresswell, Masuaku; Bowen, Rice, Soucek, Fornals; Antonio
Prediction: West Ham 1-2 Wolves
Though West Ham backed up an impressive performance against Arsenal with an even better result against Hull, they come up against a very dangerous Wolves side.
Man City were pushed all the way by a relentless Wolves side, who look as if they mean business once again ahead of another long campaign.
The Hammers are yet to keep a clean sheet this season, and with Diop out I'm anticipating a couple goals for the visitors at least.
Head to head (h2h) history and results
This will be the 66th time the two sides have met in their history, with Wolves narrowly entering as the more successful side.
The home side have won on 29 occasions, as opposed to Wolves' 22 wins, alongside 14 draws.
Wolves have beaten West Ham four times on the bounce, however, including a 2-0 win at the London Stadium last season.
Betting odds and tips
- West Ham to win: 14/5
- Wolves to win: 6/5
- Draw: Between 5/2 & 13/5
- West Ham to win 2-1: 14/1
- Both teams to score: 10/11
Odds courtesy of Betfair Exchange. Click here to find out more.
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