NBA-leading Golden State's league-record regular-season streak without consecutive losses ended at 146 games with Chicago recording a 94-87 win.
Jimmy Butler scored 22 points and Bobby Portis scored 17 points and had 13 rebounds for the Bulls.
Without the injured Kevin Durant, Golden State were led by Stephen Curry's 23 points but shot just 38.6 per cent from the field and a paltry six for 30 from three-point range.
Devin Booker had 15 points and a season-high nine assists and Marquese Chriss added 17 points for Phoenix in their 120 win over Charlotte.
The Suns shot a season-high 59.7 per cent with TJ Warren adding 16 points and eight rebounds and Eric Bledsoe 14 points.
Kemba Walker had 26 points and eight assists and Marvin Williams had 19 points for the Hornets.
Damian Lillard scored 33 points and Portland used a late 16-0 run to defeat Oklahoma City 114-109.
Jusuf Nurkic collected 18 points, 12 rebounds, six assists and five blocked shots for the Blazers.
Russell Westbrook scored 45 points for Oklahoma City but made only 12 of 36 shots from the field.