Wall Street's main indexes have ended roughly down over fears that China could resume stricter measures to fight COVID-19 after it said it faces its most severe test of the pandemic.
Beijing on Monday said it would shut businesses and schools in hard-hit districts and tighten rules for entering the city, as infections ticked higher, spooking investors.
"There is this fear that China might reinstitute some of the COVID restrictions that they've just purportedly started to lift," said Carol Schleif, deputy chief investment officer at BMO Family Office.
US casino operators with businesses in China including Wynn Resorts Ltd, Las Vegas Sands Corp, MGM Resorts International and Melco Resorts & Entertainment Ltd slipped, as well as travel stocks, American Airlines Group Inc and Norwegian Cruise Line Holdings.
According to preliminary data, the S&P 500 lost 15.22 points, or 0.38 per cent, to end at 3,950.29 points, while the Nasdaq Composite lost 121.11 points, or 1.09 per cent, to 11,024.54. The Dow Jones Industrial Average fell 42.21 points, or 0.13 per cent, to 33,703.48.
Trading volume was low on Monday, and likely to lessen towards the Thanksgiving holiday on Thursday, leaving markets more prone to volatility.
"If you want to blame a little bit of profit taking on some concerns on spikes in COVID cases, that's fine," said Jack Janasiewicz, lead portfolio strategist and portfolio manager at Natixis Investment Managers Solutions.
"It gets really tricky because of volume."
Stocks trimmed losses in early afternoon after the San Francisco Federal Reserve President Mary Daly commented that officials need to be careful to avoid a "painful downturn."
Cleveland Fed President Loretta Mester echoed Daly, saying she supports a smaller rate hike in December.
The S&P 500 energy sector index fell almost 3.0 per cent on Monday to its lowest level in four weeks as oil prices tumbled more than 5.0 per cent after a report that Saudi Arabia and other OPEC oil producers were discussing an output increase.
The index, however, pared losses after Saudi Arabia denied talks about it.
Energy was the only major S&P 500 sector eying gains for the year, surging around 63 per cent.
Walt Disney Co jumped after Bob Iger's return as chief executive to the entertainment giant.
The S&P 500 extended its fall from the previous week when multiple Federal Reserve officials reiterated the central bank's pledge to raise rates until inflation was in check, as investors now await the release of minutes from the Fed's November meeting on Wednesday.
Traders are widely betting on a 50-basis point hike in the December meeting, with a peak for rates expected in June.
Among other stocks, Tesla Inc plummeted after the electric-car maker said it will recall vehicles in the United States over an issue that may cause tail lights to intermittently fail to illuminate.
Gay dating app Grindr plummeted amid a broader market weakness, after skyrocketing in its debut on the New York Stock Exchange in the previous session.