Wall Street has ended lower, spooked by worries that the Delta coronavirus variant could blunt the economy's recovery and on uncertainty about when the US central bank may pull back its accommodative policies.
Apple and Facebook fell about 1.0 per cent after helping push the Nasdaq to record highs in the previous session.
The dips in those two Silicon Valley giants contributed more than any other companies to the S&P 500's decline for the session.
Investors have become more cautious following Friday's weak August payrolls data, while pressures from rising costs, despite the economy slowing, have increased concerns that the Fed could move sooner than expected to scale back massive monetary measures enacted last year to shield the economy from the coronavirus pandemic.
The US economy "downshifted slightly" in August as concerns grew over how the renewed surge of coronavirus cases would affect the economic recovery, the Fed said on Wednesday in its latest Beige Book compendium of anecdotal reports about the economy.
The S&P 500 has dipped less than 1.0 per cent from its record closing high last Thursday and it remains up 20 per cent year to date, buoyed by the Fed's accommodative monetary policy.
"Investors are pulling petals from a daisy, saying, 'The economy will grow, the economy won't grow,'" said Sam Stovall, chief investment strategist at CFRA.
"They can't make up their minds, so they have not commitment to long-term positions."
St Louis Federal Reserve Bank President James Bullard told the Financial Times that the Fed should move forward with a plan to trim its pandemic stimulus program despite a slowdown in job growth.
Six of the 11 S&P 500 sector indexes fell, with materials and energy the deepest decliners, down over 1 per cent each.
The Dow Jones Industrial Average fell 0.2 per cent to end at 35,031.07 points, the S&P 500 lost 0.13 per cent to 4,514.07 and the Nasdaq Composite dropped 0.57 per cent to 15,286.64.
Perrigo Company Plc jumped 9 per cent after the drug maker said it plans to buy HRA Pharma from investment firms Astorg and Goldman Sachs Asset Management in a deal valued at 1.8 billion euros ($A2.9 billion).
Cryptocurrency exchange Coinbase Global Inc fell 3.2 per cent after the US securities regulator threatened to sue the firm if it goes ahead with plans to launch a crypto lending scheme.
US payments giant PayPal Holdings Inc declined 2.7 per cent after it said it would acquire Japanese buy now, pay later firm Paidy in a $US2.7 billion ($A3.7 billion) largely cash deal.
Volume on US exchanges was 9.5 billion shares, compared with the 9.1 billion average for the full session over the last 20 trading days.
Declining issues outnumbered advancing ones on the NYSE by a 1.71-to-1 ratio; on Nasdaq, a 2.18-to-1 ratio favoured decliners.
The S&P 500 posted 32 new 52-week highs and 1 new lows; the Nasdaq Composite recorded 55 new highs and 41 new lows.