Victoria has recorded three locally acquired cases on Friday in the wake of ending its snap, five-day lockdown.
Chief Health Officer Brett Sutton had warned the state to expect more cases in the coming days despite lifting the lockdown at 11.59pm on Wednesday.
All three cases are linked to the Holiday Inn cluster, which has grown to 22.
The Department of Health said all cases were already isolating as contacts of previous cases.
Health Minister Martin Foley said the three cases are all from the same household, and two were returned travellers staying on the same floor as the family-of-three who triggered the cluster inside the Melbourne Airport facility.
It is the biggest spike in community cases for the state since February 12, when five local cases were recorded.
On Wednesday and Thursday, zero local cases were reported.
There were 21,292 people tested on Thursday.
About 3400 close contacts of positive cases remain in isolation with health authorities hopeful they have managed to contain the community spread.
Vaccine rollout for Victoria
It comes as three Victorian hospitals have been chosen to distribute the state's first doses of the Pfizer vaccine to frontline workers.
Health Minister Martin Foley has announced Austin Health, Monash Health and Western Health will be the first to deliver doses of the vaccine from Monday.
He said hotel quarantine workers, airport and port workers, high-risk frontline health staff and aged care staff and residents will be first in line for the jab.
"Our priority is to support the Commonwealth to make sure that the vaccine is administered to workers at the highest risk of contracting COVID-19 as quickly and safely possible," Mr Foley said in a statement on Friday.
"Whether they work in hotel quarantine, at the airport or a specialist COVID ward - we need to keep Victorians most at risk of infection safe, while they continue to keep Victorians safe."
The vaccine will be administered at dedicated hospital facilities, in hotel quarantine settings, at Melbourne Airport and through mobile outreach teams.
The federal government has allocated 12,000 doses of the Pfizer vaccine to Victoria in the first week of the program.
About 59,000 doses are expected in the first four weeks.
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