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A university lecturer accused of sexually abusing his daughter's 11-year-old school friend during a sleepover at his home will stand trial.

The 52-year-old, who cannot be named due to legal restrictions, appeared at Melbourne Magistrates Court today on 10 charges of sex crimes against a minor.

They are four counts of sexual penetration of a child under 16, four counts of committing an indecent act with a child under 16 and two counts of indecent assault.

He pleaded not guilty to all charges.

Fairfax reports the accused allegedly preyed on the young victim at his home on two separate occasions, including at his daughter's birthday sleepover in March last year.

It is alleged on a second occasion the accused began kissing and touching the girl in the middle of the night after watching a movie in their underwear in May, Fairfax reports.

Police allege the accused also abused the victim's younger sister - who at the time was aged eight - at a swimming pool in 2010, Fairfax reports.

The accused was bailed and is due to appear for a directions hearing on January 23.