The United States says it is removing Turkey from the F-35 fighter jet program, a move long threatened and expected after Ankara began accepting delivery of an advanced Russian missile defence system last week.
The first parts of the S-400 air defence system were flown to the Murted military air base northwest of Ankara on Friday, sealing NATO ally Turkey's deal with Russia, which Washington had struggled for months to prevent.
"The US and other F-35 partners are aligned in this decision to suspend Turkey from the program and initiate the process to formally remove Turkey from the program," Ellen Lord, the undersecretary of defence for acquisition and sustainment, told a briefing.
Turkey's foreign ministry said the move was unfair and could affect relations between the two countries.
Lord said moving the supply chain for the advanced fighter jet would cost the United States between $US500 million and $US600 million in non-recurring engineering costs.
Turkey makes more than 900 parts of the F-35, she said, adding the supply chain would transition from Turkish to mainly US factories as Turkish suppliers are removed.
"Turkey will certainly and regrettably lose jobs and future economic opportunities from this decision," Lord said. "It will no longer receive more than $US9 billion in projected work share related to the F-35 over the life of the program."
The F-35 stealth fighter jet, the most advanced aircraft in the US arsenal, is used by NATO and other US allies.
Washington is concerned that deploying the S-400 with the F-35 would allow Russia to gain too much inside information about the aircraft's stealth system.
"The F-35 cannot coexist with a Russian intelligence collection platform that will be used to learn about its advanced capabilities," the White House said in a statement earlier on Wednesday.
After the Pentagon announcement, Turkey's foreign ministry said in a statement: "We invite the United States to return from this mistake which would open irreparable wounds in strategic relations."
The S-400 acquisition is one of several issues that have frayed ties between the two allies, including a dispute over strategy in Syria east of the Euphrates River, where the US is allied with Kurdish forces that Turkey views as foes.
The Pentagon had already laid out a plan to remove Turkey from the program, which included halting training for Turkish pilots on the aircraft.
Lord said all the Turkish F-35 pilots and personnel had "firm plans" to leave the United States and were scheduled to leave by July 31.
Turkey will no longer be able to buy the 100 F-35s it had agreed to purchase.
The United States is considering expanding sales of the jets to five other nations, including Romania, Greece and Poland, as European allies bulk up their defences in the face of a strengthening Russia.