The Tottenham forward has been training in a protective mask after suffering a fractured eye socket at the start of November.
Coach Paulo Bento said ahead of the game: “Our hope is that he will feel comfortable to the greatest extent possible, and we will use the best strategies so that he can feel at ease.
“But he knows and we know that after this injury we cannot rule out any risk.”
Left back Kim Jin-su has been troubled by a hamstring injury for the last month or so but also makes the XI.
Uruguay, two-time World Cup winners, have heaps of experience in their 26-man playing party for the tournament in Qatar.
Ronald Araujo is their major injury worry - the Barcelona defender has not featured at club level for a couple of months and he is not fit for the starting XI today.
Diego Godin and Jose Gimenez reunite in central defence while Rodrigo Bentancur, Matias Vecino and Fede Valverde form one of the more balanced midfields at the tournament. Ex-Arsenal man Lucas Torreira is on the bench.
The forward line features two men who have called Liverpool home in Luis Suarez and Darwin Nunez, alongside Manchester United youngster Facundo Pellistri.
Uruguay XI: Rochet; Caceres, Godin, Gimenez, Olivera; Bentancur, Vecino; Valverde; Pellistri, Suarez, Nunez.
South Korea XI: Kim Seung-gyu; Kim Moon-hwan, Kim Min-jae, Kim Young-gwon, Kim Jin-su; Jung Woo-young, Hwang In-beom, Lee Jae-sung; Na Sang-ho, Hwang Ui-jo, Son Heung-min.