Four million Australians including the elderly and health care workers are expected to be vaccinated for COVID-19 by the end of March, as a super-infectious strain from the UK threatens the globe.
Prime Minister Scott Morrison, who will meet with state and territory leaders on Friday, announced on Thursday officials had advised him approvals for the Pfizer vaccine would be completed within weeks.
The government had earlier this week signalled early March as the start date,.
The Therapeutic Goods Administration approval process regarding another vaccine, by AstraZeneca, is due to be completed in February.
Mr Morrison said he was aware of public concern the vaccines were already being rolled out overseas, but it was important all proper checks were done to ensure their safety.
"Australia has been making its own way through this and tailoring our response to our conditions and our challenges and our needs," he told reporters in Canberra.
The Pfizer vaccine - which requires two doses a month apart - will initially be made available through up to 50 specially-equipped "hubs" as it needs to be stored at minus-70 degrees Celcius.
Once the AstraZeneca vaccine is approved, it will be made available through around 1000 sites including GP clinics and pharmacies.
The first people to be vaccinated will be quarantine and border workers, frontline health officials, aged care and disability workers and aged care residents.
Mr Morrison said it was hoped to achieve around 80,000 vaccinations a week and see that build up over a period of four to six weeks, with four million people vaccinated by the end of March.
Children will be last on the list as they are at the lowest risk of getting the virus and transmitting it.
Health Department secretary Brendan Murphy said officials had been working on plans for the rollout 24 hours a day to ensure it could be delivered safely and effectively.
It will be made available free and won't be mandatory, but vaccination will be strongly encouraged.
Mr Morrison said he would receive the vaccine at Canberra Hospital in a televised event in a bid to ensure public confidence.
The prime minister and premiers will on Friday discuss advice to strengthen the safety of end to end travel processes, from airport arrival to clearance of hotel quarantine.
Victorian Premier Dan Andrews said he would be proposing all states step up testing rates - including daily testing for those involved in the hotel quarantine process and changes to the way flight crews are handled - to deal with the "super-infectious" UK strain.
"So many parts of the world are on fire when it comes to this virus," he told reporters in Melbourne on Thursday.
"And now, with these new strains which are much more infectious than that which we've been dealing with ... if that gets in here and gets away from us there will be no pulling that up."
Queensland is on high alert for cases of community transmission after a cleaner at a quarantine hotel tested positive for COVID-19 - ending almost four months of zero locally acquired cases in the state.
Victoria reported no local, interstate or overseas acquired cases to report on Thursday - its first clean sheet since December 29.
But the state is still trying to identify the source of the state's first mystery COVID-19 case in more than two months, which has now been genomically linked to Sydney's northern beaches outbreak.
NSW recorded no locally acquired cases, but six travellers have returned positive tests. Another case related to the northern beaches was detected after the cut-off and will be included in tomorrow's figures.