But Erik Lamela and Juan Foyth could be available for selection after missing Spurs’ comeback win over Aston Villa on Sunday.
Giovani Lo Celso returned to action at Villa Park following his recovery from a thigh injury.
Julian Nagelsmann will be without Ibrahima Konate, Willi Orban and Tyler Adams for Wednesday’s tie.
Dayot Upamecano is also suspended, meaning Chelsea loanee Ethan Ampadu may have to step up for the visitors.
Here is everything you need to know:
Spurs: Lloris; Aurier, Alderweireld, Sanchez, Davies; Winks, Gedson; Lo Celso, Dele, Bergwijn; Lucas.
When is the match?
The match kicks off at 8pm at the Tottenham Hotspur Stadium.
What TV channel is it on?
The match will be shown on BT Sport 2 for UK subscribers.
Viewers can also access coverage via the BT Sport App.
Spurs will be without talisman striker Harry Kane and Moussa Sissoko, who both have long-term injuries. Erik Lamela and Juan Foyth could return after absences, but are doubts.
Leipzig have a crisis in defence with Ibrahima Konate and Willi Orban ruled out injured and Dayot Upamecano suspended. Chelsea loanee Ethan Ampadu could feature instead.
Spurs 2-1 RB Leipzig