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Dominic Thiem has pulled out of next month's Australian Open due to a long-standing wrist injury.
The 28-year-old Austrian, who has not played since suffering the injury at the Mallorca Open in June, was unable to defend his US Open title this year.
The Austrian soared to No.3 in the world until the injury which halted his progress and relegated him to No.15.
Thiem was beaten in the fourth round of the 2021 Open in three straights by Grigor Dimitrov, while last year he was beaten in five sets in the final by Novak Djokovic at Melbourne Park.
He will start his 2022 season in South America at the Cordoba Open in Argentina at the end of January.
"I will miss the Australian fans, but I will be back (there) in 2023," he said on Twitter.
"We believe this is the right decision in order to have a good return to competition.
"For the moment I will remain in Austria for a few more days and then head to practise outdoors and get ready for my first event of the season."