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Ten people were injured in three separate crashes on Perth roads overnight.

Paramedics treated eight people in Belmont about 10pm after a head-on collision sent a car crashing into the front yard of a Durban Street home.

One man was rushed to Royal Perth Hospital with serious injuries, while three more were sent to Sir Charles Gairdiner Hospital with suspected spinal injuries.

A St. John Ambulance spokeswoman confirmed another patient had been taken to Swan Districts Hospital for further treatment.

Police said the cars had collided at the intersection of Durban and Leake streets.

Just hours earlier, another crash in Belmont left a woman with serious facial injuries after her car rolled on Garratt Road.

Police are investigating reports that a bottle was thrown at her car shortly before the crash.

A crash in Menora, which saw a pedestrian taken to Royal Perth Hospital with serious injuries, is also being investigated.