UPDATE 2pm: Two people were killed and two were injured in a horrific crash in the State's north this morning.

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The driver of this Mitsubishi Outlander and a 16-year-old passenger died in the crash. Picture: Ashleigh Telford/Northern Guardian

UPDATE 2pm: Two people were killed and two were injured in a horrific crash in the State's north this morning.

The smash, between a Mitsubishi Outlander and an Isuzu truck, happened near the intersection of North West Coastal Highway and Blowholes Road at Inggarda, near Carnarvon, about 920 km north of Perth, about 7.15am.

The 60-year-old Outlander driver died in the crash, along with a 16-year-old boy who was a rear passenger.

The 82-year-old father of the Outlander driver was taken to Carnarvon Hospital by St John Ambulance with serious injuries. He remains in a serious but stable condition.

Two girls, aged 13 and 15, were also rear passengers and were not injured.

The 64-year-old truck driver sustained minor injuries and was also taken to hospital. His wife, who was a passenger in the truck, was uninjured.

The truck was towing a boat at the time of the crash.

The North West Coastal Highway was reopened a short time ago.

A police spokeswoman none of the people involved in the crash were from the area.

Carnarvon police are investigating.

The Isuzu truck involved in the smash. Picture: Ashleigh Telford/Northern Guardian
The 4WD gets towed from the crash scene this afternoon. Picture: Ashleigh Telford/Northern Guardian
The North West Coastal Highway opens after the crash. Picture: Ashleigh Telford/The West Australian

There has also been another serious crash in the State's South West today.

A woman was trapped in her vehicle after it rolled at Lake Clifton south of Mandurah on the Old Bunbury Road, about 11.55am.

The RAC Rescue helicopter transferred the woman to Royal Perth Hospital.