Perth researchers will test for the first time a combination of testosterone and fish oil to see if it helps ward off dementia.
About 400 WA men aged over 60 will be recruited into the world-first clinical trial to prevent or delay Alzheimer's disease.
The study, funded by a $500,000 State Government grant, is being led by world-renowned expert Professor Ralph Martins, from WA's McCusker Alzheimer's Research Foundation and Edith Cowan University.
Health Minister Kim Hames said WA was at the forefront of research into Alzheimer's treatment.
Dr Hames said anecdotal evidence suggested testosterone and a component of fish oil helped prevent Alzheimer's but a clinical trial investigating both substances together had not been done.
Peter Godfrey, 68, of Scarborough, does not have Alzheimer's but has been taking testosterone for 13 years without any ill-effects.
He used the supplement to treat a testosterone deficiency, which he said left him feeling unmotivated and depressed. "It's made a big difference to me, so this new study is pretty interesting," he said.
To join the trial, phone 9347 4200 or email firstname.lastname@example.org .