The Simpsons loaded with celebs
Lady Gaga and Elton John have appeared on The Simpsons. Picture: Supplied

Kristen Wiig, Zach Galifianakis, Rachel Maddow and Daniel Radcliffe will be among the celebrities lending their voices to a new season of The Simpsons.

Wiig will be heard voicing a highly-strung FBI agent whom Lisa enlists for help when she suspects that something sinister has happened to Homer, Fox said on Thursday at the Television Critics Association meeting.

Elizabeth Moss of Mad Men plays a grateful mum who names her baby after Homer when he helps deliver the child.

Marvel Comics writer Stan Lee, producer Judd Apatow and Will Arnett of Arrested Development are among other stars voicing parts on The Simpsons.

The cult show airs in Australia on the Ten Network and Fox8.

Fox's other animated series also boast a who's who of voices.

Family Guy, which also airs on Fox8, will include guest appearances by Maroon 5 singer Adam Levine playing himself, Conan O'Brien, Ashton Kutcher and Jon Cryer of Two and a Half Men, and Bryan Cranston of Breaking Bad.

American Dad, on The Comedy Channel, will feature the voices of Mariah Carey playing a redneck animal handler, Ellie Kemper of The Office, Zooey Deschanel of New Girl, Dallas Mavericks owner Mark Cuban, and Olivia Wilde of House.

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