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Four people have been charged and about 35kg of methylamphetamine with a street value of about $13m seized in a major drug operation in Perth.

The Australian Federal Police, Australian Crime Commission and Australian Customs and Border Protection Service were involved in the investigation, which police say has disrupted the Perth-based drug syndicate.

Most of the drugs seized were allegedly hidden in ceramic tiles.

Four people are due to appear in court today after raids in Wangara, Balga, Nollamara and Stirling.

Police say they seized $38,700 in cash, 2kg of a substance believed to be methylamphetamine and a stun gun during the raids.

Three men and one woman aged between 21 and 49 have been charged.

Police say investigations are continuing and have not ruled out more arrests.

Operation Kamino began on January 2.

Working on information from the ACCC, Customs and Border Protection officers examined a container from China which arrived in Fremantle.

Customs and Border Protection officers' inspected the consignment which contained 17 pallets of ceramic tiles.

Authorities say a substance concealed within the tiles tested positive for methylamphetamine.

The four people were arrested yesterday after the AFP conducted a controlled delivery.

They have been charged with attempting to possess a border controlled drug, methylamphetamine.

The maximum penalty is life imprisonment and/or an $825,000 fine.