Nicole Kidman will go home empty handed after missing out on two SAG awards.
The Australian was nominated for her role in the TV movie Hemingway & Gellhorn, but the SAG went to Julianne Moore for her portrayal of former US vice presidential candidate Sarah Palin in Game Change.
Kidman was also up for a supporting actress award for her sexually-charged performance in The Paperboy, but Anne Hathaway won for her role in Les Miserables, as a doomed single mother forced into prostitution in the adaptation of the stage musical based on Victor Hugo's epic novel.
Her win came over four past Oscar recipients - Sally Field, Helen Hunt, Kidman and Maggie Smith.
“I'm just thrilled I have dental,” Hathaway said.
"I got my SAG card when I was 14. It felt like the beginning of the world. I have loved every single minute of my life as an actor. ... Thank you for nominating me alongside incredible women and incredible performances.”
Tommy Lee Jones won the first prize of the night for Lincoln.
Jones was not at the show, but the win improves his odds to become a two-time Academy Award winner.
He previously won a supporting-actor Oscar for The Fugitive.
On the television side, with 30 Rock ending its run, its stars Tina Fey and Alec Baldwin won the SAG awards for best comedy performers.
It was Baldwin's seventh-straight win, while Fey earned her fifth SAG prize.
“Oh, my God. It's ridiculous,” Baldwin said. “It's the end of our show, which is sad. Everybody is sad about that. It was the greatest experience I've ever had.”
Fey gave a plug for the show's finale airing in the US on Thursday, noting that it's up against The Big Bang Theory.
“Just tape The Big Bang Theory for once, for crying out loud,” Fey said.
Modern Family won for best overall cast in a TV comedy show. Accepting for the cast, Modern Family co-star Jesse Tyler Ferguson offered thanks to the makers of 30 Rock and another departing series, The Office, saying “you all have set the comedy bar so high”.
Ferguson joked that if the 30 Rock or The Office stars need jobs, they should contact the Modern Family casting director.
Earlier, the James Bond adventure Skyfall and the fantasy series Game of Thrones picked up prizes for best stunt work, honours announced on the red carpet before the official SAG Awards ceremony.
JoBeth Williams and Scott Bakula announced the winners, noting the value of stunt players, who often are overlooked for their contributions to film and television.
“The stunt men and women of our union are critical to the work that gets done,” Bakula said.
“They keep us healthy, they keep us alive, they keep us working. They keep our shows working.”
Receiving the guild's life-achievement award is Dick Van Dyke, who presented the same prize last year to his The Dick Van Dyke Show co-star, Mary Tyler Moore.
Van Dyke's award was to be presented by his 1960s sitcom's creator and co-star, Carl Reiner, and Alec Baldwin.
“I'm so tickled. I'm so excited,” Van Dyke said before the show. “And I'm the only one who knows he's going to win.”