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Justin Theroux and Jennifer Aniston. Picture: John Shearer/Invision/AP

It looks like things could well and truly be over for Jennifer Aniston and her fiance Justin Theroux. The former Friends star celebrated her 45th birthday this week with her close friends, including Courteney Cox, at Los Angeles' Soho House but Theroux was not to be seen.

The actor was spotted partying with his good mate Orlando Bloom at a store launch, where he was deemed to be "upbeat and laughing".

Aniston's birthday wasn't the first time one half of the couple, above, was missing from an important occasion. She was also absent when Theroux attended the funeral of his friend Philip Seymour Hoffman in New York last weekend.