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Will Kopelman and Drew Barrymore. Picture: Getty Images

Drew Barrymore and her mother "can't be in each other's lives".

The actress - who never spent much time with her actor father John, who died in 2004 - has always had a strained relationship with her mum Jaid and has mixed feelings toward her, so the two women find it better to keep their distance from one another.

"When I was a kid, everything was so unplanned, my parents were so erratic, and my world was so inconsistent. I hated growing up alone. I hated it ... I don't f**k anyone over. My friends are the loves my life," Barrymore said.

"Ugh, I mean, my relationship with my mom is so complicated that ... I've always been empathetic toward my mom, and I was even more so when I had a kid and we had a really amazing conversation about it.

"However, it hasn't enabled me to lessen the distance. It's the hardest subject in my life. I've never just been angry with her. I've always felt guilt and empathy and utter sensitivity. But we can't really be in each other's lives at this point."

The 38-year-old star - who is expecting her second child, a sister for 15-month-old daughter Olive - says she has found the stable home life she has always desired in the family of her husband Will Kopelman.

"I didn't think I would ever get to experience that. This is so safe and positive and healthy because they have their values intact," Barrymore told the new issue of America's Marie Claire magazine.

"It was huge for me. And that's what I want for my family."

And though she hasn't yet given birth to her second child, Barrymore admits she and her spouse are already planning a third baby.

"I think I'd like to have more. In the back of my head, I'm already timing if I was to have another when that would occur," she said.