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Theranos founder Elizabeth Holmes is not a villain but rather a hard-working, young and naive businesswoman whose company simply failed, her lawyer has told jurors at the former Silicon Valley star's trial on federal fraud charges involving the now-defunct blood-testing start-up.
Lance Wade, a lawyer for Holmes, delivered the defence's opening statement in one of the most closely watched trials of a US corporate executive in years.
Wade spoke after the prosecution in its opening statement said Holmes had engaged in a scheme of "lying and cheating" to attain wealth and fame at the expense of investors and patients.
Holmes is accused of making false claims about Theranos, including that its devices - designed to draw a drop of blood from a finger prick - could run a range of tests more quickly and accurately than conventional laboratory means.
"In the end, Theranos failed and Ms Holmes walked away with nothing," Wade told jurors in San Jose, California.
"But failure is not a crime. Trying your hardest and coming up short is not a crime. And by the time this trial is over, you will see that the villain the government just presented is actually a living, breathing human being who did her very best each and every day. And she is innocent," Wade added.
Holmes, 37, has pleaded not guilty to 10 counts of wire fraud and two counts of conspiracy.
She may testify during the trial.
"This is a case about fraud - about lying and cheating to get money," Robert Leach, a member of the prosecution team, earlier told the 12-member jury.
"The scheme brought her fame, it brought her honour and it brought her adoration," Leach added, also making her a billionaire.
"She had become, as she sought, one of the most celebrated CEOs in Silicon Valley and the world. But under the facade of Theranos' success there were significant problems brewing," Leach said.
The defence countered that portrayal, with Wade telling jurors: "Elizabeth Holmes did not go to work every day intending to lie, cheat and steal. The government would have you believe her company, her entire life, is a fraud. That is wrong. That is not true."
On paper, Theranos was worth billion of dollars but when Holmes left it in 2018, her savings, her stock and the company were "all gone," Wade said.
Wade asked jurors to ponder whether Theranos failed because its technology was a fraud or "because a young CEO and her company confronted and could not overcome business obstacles that others saw but she naively underestimated?".
Wade said Holmes dropped out of prestigious Stanford University and bet her savings to start Theranos at age 19 in 2003, then poured her life into it for 15 years.
Holmes grabbed headlines with her vision of a small machine that could run blood tests in stores and homes.
"She was all in on Theranos, motivated by its mission, not money, committed to that mission until that very last day," Wade said.
Holmes sat at a table flanked by her lawyers.
US District Judge Edward Davila is presiding.
Former Theranos executive Ramesh "Sunny" Balwani, scheduled to be tried separately, has also pleaded not guilty.
Court filings showed that Holmes, who had a romantic relationship with Balwani, has alleged he abused her emotionally and psychologically.
Balwani has denied the allegations.
Leach said evidence will show Holmes agreed with Balwani to carry out a scheme to defraud Theranos investors and patients.
In 2009, after losing interest from Pfizer Inc and other pharmaceutical companies, Holmes turned to fraud, Leach said.
"Out of time and out of money, Elizabeth Holmes decided to lie," Leach said.
Prosecutors have said Holmes and Balwani defrauded investors between 2010 and 2015 and deceived patients when the company began making its tests commercially available, including via a partnership with the Walgreens drugstore chain.
The Wall Street Journal in 2015 reported that the Theranos devices were flawed and inaccurate, setting off a downward spiral for a company that had drawn investors including media mogul Rupert Murdoch and Oracle co-founder Larry Ellison.