A teenage girl has died after a car crash at a popular Melbourne restaurant strip which injured four other people.

The 16-year-old girl from Brunswick was critically injured when a gold Volkswagen Passat and a blue Alfa Romeo she was travelling in collided along the Lygon St precinct in Carlton about midday on Saturday.

She was rushed to hospital but died of her injuries on Wednesday.

The driver of the Volkswagen, Gulet Ahmed, 40, was previously charged on Sunday.

Eyewitnesses claimed the Alfa Romeo struck two pedestrians during the collision.

Two other occupants of the Alfa Romeo, a 61-year-old man and a 53-year-old woman, both from Brunswick, were hospitalised with non-life-threatening injuries.

The two pedestrians, a 42-year-old man and a 40-year-old man, both from Carlton, were taken to hospital with non-life-threatening injuries.

Mr Gulet has been charged with dangerous driving causing serious injury and methylamphetamine possession.

He was remanded in custody to appear in court at a later date.