Viktoria Rebensburg and Sofia Goggia suffered season-ending injuries on Sunday after heavy falls in the women's super-G World Cup race in Garmisch-Partenkirche,won by Corinne Suter.
Switzerland's Suter, who finished fifth in Saturday's downhill won by Germany's Rebensburg, clocked 1min 19.46sec down the testing Kandahar course.
Austria's Nicole Schmidhofer was second at 0.43sec back with Swiss Wendy Holdener third at 0.70.
"I'm very happy with the performance, but it wasn't free of mistakes. It was very icy and difficult on the course," said Suter.
The pre-race favourite, the super-G standings leader Federica Brignone of Italy, finished fifth at 0.90sec back.
Overall World Cup leader Mikaela Shiffrin was absent in Garmisch following the death of her father last week.
After finishing second in Saturday's downhill, Brignone, who is second in the overall rankings, has now trimmed Shiffrin's lead to 145 points.
This was Suter's second World Cup win of the season after winning the downhill in Altenmarkt, Austria, last month.
Despite racing under clear-blue skies, the course was especially testing having iced up overnight following mild day-time conditions in the Bavarian Alps.
Ester Ledecka, the Czech Republic's reigning 2018 Olympic super-G champion, could only manage 17th, 2.06sec behind Suter.
The Kandahar proved too much for local favourite Rebensburg, who suffered a knee injury, and Olympic downhill champion Goggia, who broke her arm.
After claiming the first downhill win of her career 24 hours before, giant slalom specialist Rebensburg was the victim of a heavy fall on the mid-section nicknamed 'Hell'.
The 30-year-old lost control of her outside ski on a turn and crashed into the safety netting.
Although she was able to ski down, a hospital scan revealed a compression fracture in her left knee and ligament damage, the German Ski Association (DSV) announced.
"It's bitter news that the season is over for me," said Rebensburg in a statement.
"I had a bit of luck in my bad luck as all ligaments are intact and I am confident I will be skiing again soon once my rebah is over."
Italy's Goggia broke her left arm, which struck a gate, after also falling in the mid-section, and is ruled out for at least the next six weeks.
The 27-year-old was in visible distress after her upper body took the brunt of a crash into one of the plastic gates on the piste.
Switzerland's Corinne Suter claimed her second World Cup win of the season when she won the women's super-G race in Garmisch-Partenkirchen on Sunday.
Italy's Sofia Goggia nurses her left arm which she fractured after a crash in the women's super-G World Cup race in Garmisch-Partenkirchen on Sunday.