Voluntary redundancies are being offered to staff at major public hospitals in Adelaide in a move to cut costs and ensure the network operates "within our means".
SA Health says it doesn't have a particular target for the number of positions to be axed and will consider each application on its merits.
"We need to operate within our means, and to bring the Central Adelaide Local Health Network back to a size and a shape that will allow us to realise the ambition that we have for the future," chief executive Lesley Dwyer said on Thursday.
The job cuts are part of moves by the state government to bring the health network's budget under control after a series of large blowouts over recent years.
Ms Dwyer said the redundancies would support the continued financial recovery and improve efficiencies.
"Over the past few months, we have been redesigning the way we work to ensure service delivery continues to put patients at the centre of everything we do, and so that we can become more efficient in the way we do things," she said.
"This process is not about targeting individual staff; rather offering voluntary separation packages gives us the opportunity to realign our resources."
But the Labor opposition has expressed concern that much-needed doctors and nurses would be among those to go.
"These job cuts will make our hospitals worse, not better," Health Spokesman Chris Picton said.
"What's worse, doctors and nurses could go in the new wave of job cuts unleashed."
Mr Picton said up to 1100 jobs could be axed as the government tried to save $470 million over the next three years.