Firefighters had to rescue their colleagues from a massive factory fire, with two rushed to hospital in a serious condition.

Two female firefighters have been hospitalised, including one in a critical condition, after the fire broke out at a factory south of Brisbane overnight.

Some of the 45 firefighters involved in the operation had to be rescued from the blaze, Queensland Fire and Emergency Service Deputy Commissioner Michael Wassing told reporters.

There were 18 fire trucks on the scene as part of a major effort to contain a blaze on the Pacific Highway at Slacks Creek.

The fire was finally extinguished at about 6am and a crime scene has since been declared.

Emergency crews were called just before 2.30am to reports of large amounts of black smoke.

A man suffered minor injuries and was also transported to hospital.

A warning was issued to residents in the neighbouring area just after 3am to shut doors and windows as smoke gushed from the site.

“There is a large amount of smoke in the surrounding area, including Springwood,” a Queensland Fire and Emergency Services spokesman said.

“Nearby residents are asked to close windows and doors and those suffering from a respiratory condition should keep medications close by.”

Traffic on the Pacific Highway was “seriously affected” and motorists were being urged to drive with caution.