Fishing bans, pollution controls and other measures to keep dolphins safe in Adelaide's Port River will be considered by a state parliamentary committee.
The upper house inquiry will look at ways to protect the animals in the Adelaide Dolphin Sanctuary.
It will consider the impact of dredging in the river as well as bans on heavy gauge fishing practices including the use of large hooks, live bait and trawling.
Other issues include river pollution and the need for increased water quality monitoring, further speed restrictions on the waterway and increasing the number of marine inspectors.
Greens MP Tammy Franks said it was time Adelaide had a dolphin sanctuary that actually kept dolphins safe after a spate of recent deaths.
"The pollution in the Port River has been an issue for a long time, and as is the case when these issues go without being adequately addressed, we are seeing the consequences of that," she said.
"It is clear that these dolphins are suffering, that they are dying, and that we humans are not innocent in the pollution of the Port River that is proving to be so harmful.
"We need to ensure that everything is being done to better treat and care for the dolphins who are currently suffering."
Ms Franks said it was hoped the committee's investigations would provide some real answers and prompt action to keep the dolphins safe.