Just four points separate these two Championship sides, meaning both QPR and Wednesday will be confident of making it into the fifth round of the competition.
Neither team has been in particularly good form of late, but recent results go out the window when it comes to cup football.
With kick-off scheduled for 8pm GMT, follow all the goals and action with Malik Ouzia at the Kiyan Prince Foundation Stadium.
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How to watch QPR vs Sheffield Wednesday
TV channel: The match will be televised live on BT Sport 1 Extra HD and BT Sport Ultimate, with coverage starting from 7.45pm.
QPR vs Sheffield Wednesday teams
QPR: Lumley, Kane, Leistner, Masterson, Manning, Ball, Clarke, Chair, Eze, Pugh, Hugill
Subs: Barnes, Hall, Cameron, Amos, Shodipo, Osayi-Samuel, Wells
Sheffield Wednesday: Dawson, Fox, Borner, Lees, Odubajo, Hutchinson, Pelupessy, Harris, Murphy, Winnall, Rhodes
Subs: Wildsmith, Nuhiu, Reach, Borukov, Iorfa, Hunt, Urhoghide
QPR vs Sheffield Wednesday head to head (H2H) results
- QPR wins: 25
- Draws: 17
- Wednesday wins: 30
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