Authorities are reeling after a horror weekend on Victoria's roads, with police saying the eight fatalities are a reminder of the "fragility of life".
Assistant Commissioner Doug Fryer urged motorists to slow down and take care.
"I've never seen anything like those numbers since I've been in this role," he told reporters on Sunday.
"The message if anything is the fragility of life, you've got people driving around in two tons of steel coupled with speed, coupled with complacency."
Mr Fryer was speaking at a road safety event with Road Safety Minister Luke Donnellan in Melbourne.
"In April, I say this in an unusual way, we only lost 10 people's lives... that was the best month we've had since we started collecting statistics," Mr Donnellan said.
"This weekend, that just smashed those figures out of the water and just highlighted to us all we need to work together with road safety, we need to take individual responsibility, we need to drive to the conditions."
On Sunday morning one driver lost control and went through a farm fence at Heathcote Junction. He died at the scene but his four passengers escaped unhurt.
A second driver died when his car left the roadway and struck a tree at Bright on the Great Alpine Road about 10.35pm on Saturday.
The man was alone in the vehicle and died before he could be taken to hospital.
On Saturday four women were killed when the car they were in was T-boned by another at Navarre as they were coming home from linedancing.
The two women in the front died holding hands and all four women died from internal injuries, Mr Fryer said.
"The sight of the driver holding the passenger's hand as she passed will haunt me for some time," he said.
Earlier on Saturday a 58-year-old man died after his motorcycle collided with a bus and a woman who was a passenger died when the car she was in crashed into an embankment at Dixons Creek.