Pedestrians hit by car in Melbourne CBD

Marnie Banger and Georgie Moore

A driver is on the run after hitting up to four pedestrians in Melbourne's CBD.

The people were struck on A'Beckett Street near Queen Street, just after 5pm on Tuesday, police said in a statement.

Police do not believe the incident is terror related but have urged people to avoid the area.

A man in his 20s or 30s who was hit on Queen Street has been taken by ambulance to the Alfred Hospital with the nature of his injuries not yet clear, an Ambulance Victoria spokeswoman told AAP.

Another two pedestrians were assessed by paramedics at a nearby intersection after the car hit a traffic pole. They did not wish to be taken to hospital.

Witness Troy Naismith said he watched from his balcony as a car hit at least one other vehicle and a traffic light within about 20 seconds on A'Beckett street, before its male driver fled.

"He ping-ponged into this car here, into the traffic light, knocked the traffic light over, and then hopped out the car and ran off up the road," he told reporters at the scene.