Israeli gunfire has killed a 21-year-old Palestinian man and 69 others have been wounded on the Gaza-Israel border as protesters stream the frontier as the United States prepares to officially open its embassy in Jerusalem.
Gaza's health ministry says the man was shot dead near the southeastern town of Khan Younis and that nine of the wounded are in a serious condition, and other protesters have been overcome by tear gas.
Thousands of Palestinians are protesting near Gaza's border with Israel, and the territory's Hamas leaders have suggested a border breach is possible. Israel has warned it would block such a breach at any cost.
It comes as US officials and US President Donald Trump's daughter Ivanka Trump and her husband Jared Kushner attend a ceremony in Jerusalem to commemorate the official opening of the new US Embassy, that has moved from Tel Aviv.
Trump's Middle East negotiator Jason Greenblatt has tweeted that "the long-overdue step of moving our embassy is not a departure from our strong commitment to facilitate a lasting peace deal".
However, a senior aide to Palestinian President Mahmoud Abbas says the decision violates a promise to hold off on moving the embassy to give peace talks a chance.
Protests are expected to escalate during Monday, the 70th anniversary of Israel's founding, as loudspeakers on Gaza mosques urged Palestinians to join the so-called "Great March of Return".
Israeli troops have killed 45 Palestinians since the demonstrations began on March 30, according to Palestinian health officials, while no Israeli casualties have been reported.
The death toll has drawn international criticism, but the US, which has drawn Arab anger by relocating its embassy to Jerusalem from Tel Aviv, has echoed Israel in accusing Gaza's ruling Hamas movement of instigating violence.
The protests are scheduled to culminate on Tuesday, the day Palestinians mourn as the "Nakba" or "Catastrophe" when, in 1948, hundreds of thousands of them were driven out of their homes.
Naftali Bennett, Israel's education minister, told Israel Radio that Israel would treat the Gaza fence as an "Iron Wall" and anyone who approached it as a "terrorist".