Face masks and COVID-19 social distancing health rules are set to be eased in Darwin and Alice Springs.
Northern Territory Chief Minister Michael Gunner says it's a "bittersweet" moment after an outbreak linked to a Newmont mine in central Australia was brought under control.
"The lockdown worked. We trapped the virus and we made sure it wasn't community spread," he told Mix FM in Darwin on Wednesday.
"Territorians have been magnificent. Things are looking good. I think we're absolutely on track (to lift restrictions) on Friday."
But the Chief, as he's known in the NT, said it had come at a cost to many casual workers and small businesses.
Many were unable to work during a five-day lockdown that ended on Friday, he said.
"It's bittersweet that we've got to where we've got to. We're safe because a lot of people made sacrifices."
Other health restrictions to be relaxed on Friday include a 10-person limit on the number of people permitted at private residences.
Patrons won't be required to sit down at hospitality venues while indoor exercise venues, such as gyms, and markets will reopen.
It comes as NT Health opens a new COVID-19 vaccination centre in the Darwin suburb of Marrara.
The centre will be open for extended hours and on weekends if enough Pfizer vaccine is available.
Pharmacist in charge of the NT's rollout, Bhavini Patel, says the territory has about 7000 doses available for July and August with the federal government promising more from September.
The new centre can handle 120 clients per day with 2000 appointments already booked in.
Priority will be given to Indigenous Australians, people aged 40 to 59 years, people who meet the Phase 1A and 1B criteria and people aged 16 to 39 years with a medical condition.
Health, quarantine, aged care, disability, high-risk industry and border workers will also be eligible, along with people with an exemption to travel overseas
More than 40 per cent of Territorians have received at least one dose of a COVID-19 vaccine.
That's about 100,000 people out of the NT's 246,561 residents, with about 16 per cent or 30,000 people given their second dose and fully vaccinated.
"We hope to get most Territorians vaccinated either by the end of the year or early next year depending on supply," Dr Patel said.
The virus outbreak at Newmont's Granites Mine, about 540km northwest of Alice Springs, started on June 26 and led to 18 people becoming infected across Australia.
There have been no new cases since Friday.