While more than 90 per cent of adults in NSW are fully vaccinated against COVID-19 and infections continue a downward trend, the virus is still claiming the lives of the unvaccinated.
NSW recorded 216 new COVID-19 cases and three deaths in the 24-hours until 8pm on Tuesday, with the death toll from the latest outbreak now at 550.
A man in his 30s from southwestern Sydney who wasn't vaccinated and had underlying health conditions was among the latest casualties.
Another unvaccinated man in his 40s from southwestern Sydney also died as well as a man in his 80s from southwestern Sydney, who had received one jab.
NSW has now exceeded the long-awaited 90 per cent full COVID-19 vaccination milestone and is aiming to get to 95 per cent.
NSW Health's Marianne Gale said the high vaccination rate was "really pleasing".
"While we've achieved that terrific milestone ... if you haven't yet been vaccinated please don't delay," she said.
She urged anyone who had recovered from the virus to get vaccinated.
"If you have any doubt please talk to your GP," she said.
As predicted by health authorities, COVID-19 has become the disease of the unvaccinated and remains as deadly as ever for those with no immunity.
"We need to remain vigilant and we need to continue to increase our efforts to maintain and further enhance those vaccination coverage rates," Dr Gale said.
She singled out 12 to 15-year-olds to get step up and get the jab - 80.2 per cent have had their first dose and 70.4 per cent are fully vaccinated.
Some 94 per cent of people 16 and older have had one jab and 90.1 per cent of adults have had two doses.
Six fewer cases of the virus were reported on Wednesday compared with the previous day, while the number of COVID-19 patients in hospital dropped by 19 to 235.
The state has 41 COVID-19 patients in intensive care, 17 of whom are ventilated.
The number of tests jumped to 95,804 from 66,680 the previous day.
More than 12.5 million vaccines have been administered in NSW.
With 46 new cases, the Hunter New England Local Health District continues to be the biggest hotspot, followed by southwest Sydney, which had 37 while 31 are from southeast Sydney.
NSW Health's ongoing sewage surveillance program has detected fragments of the virus from Barraba, Gulgong and Young, where there are no known cases.
Meanwhile, South Eastern Sydney Local Health District has been notified about 11 confirmed cases of COVID-19 associated with Barry's Bootcamp gyms at Kings Cross, Surry Hills and Martin Place.
NSW Health is contacting people who attended "classes of concern" between October 30 and November 4.
Anyone who attended any of the classes between those dates and who hasn't been contacted should monitor for symptoms of COVID-19 and immediately get tested and isolate until a negative result.