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Five interstate truck drivers have tested positive for COVID-19 after travelling through South Australia in the past six days, as health authorities also express fears over positive wastewater results.
SA Chief Public Health Officer Nicola Spurrier said the figure includes two NSW truck drivers identified at the weekend who travelled through the state's north and west last week.
Health authorities were also made aware of another COVID-positive NSW truck driver on Tuesday before a further two cases came to light on Wednesday.
"We are under extreme time pressure here to protect the South Australian community," Professor Spurrier told reporters, urging people to check for fresh exposure sites and get tested if they have symptoms.
About 240 people have already been placed in self-isolation as close contacts, but Prof Spurrier expects that number to grow from the latest two cases.
It is believed all five truck drivers caught the virus interstate before entering SA, with the cases picked up as part of mandatory three-day surveillance testing for those coming from NSW and Victoria.
Prof Spurrier said the public health team had informed her all the interstate truck drivers had complied with health directions to wear a mask.
"It's a real wake-up call here for us in South Australia," she said.
"The risk from NSW and also Victoria is not going away. It's a very real risk for everybody."
There were also two positive wastewater detections late on Tuesday, one in the Salisbury area and the other in Adelaide's south.
"Until we have lots and lots of people getting tested, I can't feel reassured that we don't have community transmission," Prof Spurrier said.
She conceded it was a matter of time before the state, which shares borders with COVID-battered NSW and Victoria, has another outbreak.
"The risk is so very high for us here in South Australia at this point in time," Prof Spurrier said.
"We want to give ourselves every chance of being able to get on top of it so we are not in an extended lockdown."