Chancellor Angela Merkel has urged Germans to accept nationwide pandemic restrictions that came into force at midnight, resulting in a 10pm-5am curfews, further limits on personal contacts and access to non-essential stores in regions with high infection rates.
In her weekly video address on Saturday, Merkel acknowledged the new rules were tough but insisted they were needed to curb the spread of the virus.
Germany's disease control agency on Friday reported 23,392 newly confirmed cases and more 286 deaths from COVID-19.
Since the start of the pandemic, Germany has recorded almost 3.3 million cases and 81,444 deaths.
Merkel said the new measures, which automatically come into force in regions with more than 100 newly reported cases a week per 100,000 inhabitants, were "urgently needed".
Citing other countries such as Britain, Portugal and Ireland that saw infection rates sharply reduced during strict lockdowns, she defended Germany's new restrictions against critics who have called them excessive.
"No country that managed to break the third wave of the pandemic and then loosen restrictions again did so without tough measures such as night-time curfews," Merkel said.