Men at large after Melb CBD hit-run crash

Two men who fled an allegedly stolen car after it struck a pedestrian and three other vehicles in the Melbourne CBD remain on the run.

The pair, a driver and passenger, ran away after the Toyota Camry hit a man and the cars on A'Beckett Street, soon after police tried to intercept the car on Flinders Street at about 5pm on Tuesday.

The struck man, aged in his 20s or 30s, was taken to the Alfred Hospital with serious injuries but was in a stable condition on Tuesday evening.

Police do not believe the incident was terror related but initially urged people to avoid the area as they closed roads to investigate.

Witness Troy Naismith said he watched from his balcony as a car hit at least one other vehicle and a traffic light within about 20 seconds on A'Beckett street, before its driver fled.

"He ping-ponged into this car here, into the traffic light, knocked the traffic light over, and then hopped out the car and ran off up the road," he told reporters at the scene.

Police first believed another CBD crash on Market Street was connected to the A'Beckett incident, but later determined it was "completely separate".

In that crash, two people were assessed by paramedics after a car hit a traffic pole, and did not wish to be taken to hospital.