The 24-year-old came off the bench in the win over Liverpool on the weekend and has been widely praised for his impact in north London following a free transfer arrival in the summer.
However, he is understood to have suffered an injury in training.
Spurs are currently assessing Solomon and are yet to discover the full extent of the issue, amid reports that he is set for an extended spell on the sidelines.
Injuries are slowly mounting for Ange Postecoglou, who contended with knocks affecting James Maddison and Heung-min Son before both started the match against Liverpool.
Brennan Johnson is a doubt for the weekend’s game at Luton due to a hamstring issue, while Ryan Sessegnon is back in light training after summer surgery on his hamstring.
Ivan Perisic is out long-term while Rodrigo Bentancur, Bryan Gil and Giovani Lo Celso are also currently unavailable.