The Red Devils got off to the perfect start in the group stage, beating Paris Saint-Germain on the road in gameweek one.
They head into this game off the back of a clean sheet in the Premier League against Chelsea and will be hopeful of another positive result.
Leipzig saw off Istanbul Basaksehir in their opener and will aim to take a big step towards qualification with all three points at Old Trafford.
Hereâs everything you need to know:
What time is the match?
The match kicks off at 8pm on Wednesday 28 October at Old Trafford.
What TV channel is it on?
The game is being broadcast on BT Sport 2 and BT Sport Ultimate.
Subscribers can also stream the match via the BT Sport website as well as the BT Sport app.
MUN: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Matic, Pogba, Fred, Van de Beek, Greenwood, Martial
RBL: Gulacsi, Angelino, Upamecano, Konate, Poulsen, Forsberg, Nkunku, Halstenberg, Olmo, Henrichs, Kampl
Leipzig are a quality side and will present United with significant problems. That said, United delivered on the biggest stage last week against PSG and will be hopeful a similar level of performance can bring with it an equally positive result - if they can find a similarly strong defensive display. Manchester United 2-2 RB Leipzig