Man, 25, stabbed in Adelaide CBD on Anzac Day

South Australia police are seeking the public's help following the fatal stabbing of a man in the Adelaide CBD in the early hours of Monday morning.

Police were called to the CBD just after 2am on Monday after a man was found lying on the road at the intersection of North Terrace and George Street.

When officers arrived they found the 25-year-old Victorian man with multiple stab wounds to his chest.

Sadly, he died shortly after.

"The circumstances of that murder are that the attackers ran down the victim," Assistant Commissioner John Venditto said during a media conference.

"And when he fell he was stabbed while he was on the ground and assaulted."

Twelve men and one boy have been arrested over "a series of skirmishes and confrontations" in the Adelaide CBD, however, no one has been charged with the murder.

Vehicle of interested searched, weapons found

South Australia police said in a statement it does not appear to be a random incident.

Detectives from Eastern District CIB and Forensic Crime Scene Investigators were recalled to the scene and are investigating. Detectives from Operation Meld are also assisting with the investigations.

Seven of the men were arrested after inquiries at a hotel on Franklin Street.

The other five, including the 16-year-old boy, were arrested in Pulteney Street.

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Officers searched a vehicle of interest, a blue Holden sedan, and located two knives, a machete and cash.

Police are yet to determine whether the arrested men are linked to the stabbing on North Terrace.

All men were refused bail or did not apply for bail and will appear in the Adelaide Magistrates Court on Tuesday.

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