Man dies during arrest on Melbourne road

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A man has died while being arrested by police in Melbourne's southeast, triggering a homicide investigation.

Police patrolling High Street in Cranbourne spotted a 32-year-old man walking in traffic just before midnight on Tuesday.

He was asked to get off the road but didn't follow the request and became aggressive towards the officers, police said.

When they tried to arrest him, the man appeared to suffer a medical condition and died at the scene despite resuscitation attempts.

Homicide squad detectives will investigate the death with oversight from Victoria Police's Professional Standards Command.

"This is standard protocol when a person has died in police custody," police said.