The two meet in the Champions League quarter-final in Portugal, with City heavy favourites after seeing off Real Madrid in the last 16.
Lyon did similarly well to beat Juventus on away goals, but face a big test to go any further—an exit would mean no European football for them next season.
Pep Guardiola‘s side will hope to face the winners of Barcelona and Bayern Munich in the next round.
Here’s all you need to know about the game.
When is it and what time is kick-off?
The match will begin at 8pm BST on Saturday 15 August at Estadio Jose Alvalade in Lisbon.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 1 and BT Sport Extra 1, as well as BT Sport Ultimate.
Subscribers can also stream the match on the BT Sport website and app.
Manchester City should have a fully fit squad to choose from, other than long-term absentee Sergio Aguero. Guardiola will need to choose between Phil Foden and Riyad Mahrez in attack in particular.
Lyon are in similarly good shape and Rudi Garcia could name an unchanged lineup, though there is a case to recall Moussa Dembele up front in place of Karl Toko-Ekambi.
Man City: Ederson, Walker, Garcia, Laporte, Cancelo, Fernandinho (C), Rodrigo, Gundogan, De Bruyne, Sterling, Jesus
Lyon: Lopes, Denayer, Marcelo, Aouar, Depay, Dubois, Marçal, Ekambi, Caqueret, Cornet, Bruno Guimarães
Man City — 3/10
Draw — 11/2
Lyon — 11/1