Ole Gunnar Solskjaer’s men currently sit in fifth place and know that a victory is needed in order to keep their top-four hopes alive.
Defeat to Liverpool, though, will leave United 30 points behind the top spot.
Jurgen Klopp’s side are unbeaten so far in the Premier League, securing 61 points from a possible 63.
Liverpool’s 20 wins from 21 games makes it appear certain that their 30-year wait for a league title is almost over.
When is it?
Liverpool vs Manchester United kicks off at 16:30 on Sunday 19 January.
How can I watch it?
You can watch the game live on Sky Sports Premier League and Main Event.
The game can be streamed online via the Sky Sports App and Sky Go from 4:00pm
Jurgen Klopp has said he is optimistic that Fabinho will return from injury on Sunday after being side-lined for the last two months with an ankle problem.
Joel Matip, whose last appearance was in the October draw at United, and Dejan Lovren are also likely to return having recovered from injuries.
Ole Gunnar Solskjaer has confirmed that Eric Bailly, who has not played a first- team match for close to six months due to a knee injury, could be named in this weekend’s squad.
Luke Shaw’s and Jesse Lingard’s involvement in this weekend’s clash is in doubt after both being reported as ill.
Axel Tuanzebe, Marcos Rojo, Scott McTominay and Paul Pogba are all still out with injury, with no precise date given as to when they will return.
Liverpool XI: Alisson, Alexander- Arnold, Matip, Van Dijk, Robertson, Milner, Fabinho, Wijnaldum, Salah, Firmino, Mane.
Manchester United XI: De Gea, Wan-Bissaka, Lindelof, Jones, Williams, Fred, Matic, James, Mata, Greenwood, Rashford.
Liverpool to win: 2/5
Manchester United to win: 6/1
Liverpool are the likely winners of this clash.
The Reds have not lost a league match at Anfield since April 2017 and are unbeaten this season.
But with a full week separating Liverpool’s win over Tottenham and their meeting with Manchester United, Klopp has warned that the break in rhythm might be a challenge for his players.
United are the only team to take a point from Klopp’s men this season, but will be underdogs this time around.