At least 58 people were injured when a passenger train derailed south of Egypt's capital Cairo, the health ministry said in a statement.
"Most of the injuries are minor," Ahmed Mohei, an assistant to the health minister, told state television on Friday.
Three carriages on a train headed to the southern province of Qena went off-track, state news agency MENA said, citing a transport ministry statement.
Public Prosecutor Nabil Sadek ordered an investigation into the accident by a technical team from the Armed Forces Engineering Authority.
The prosecutor also summoned a number of railway officials for questioning.
Egyptians have long complained that governments have failed to enforce safety on the antiquated rail network.
Figures by Egypt's official statistics agency show that 1793 train accidents took place in 2017.
In March, President Abdel-Fattah el-Sisi said the government lacks about 250 billion Egyptian pounds ($18.9b) to overhaul the country's run-down railway system.
His remarks came a day after a passenger train collided with a cargo train in Egypt, killing at least 12 people, including a child.
In 2016, at least 51 people were killed when two commuter trains collided near Cairo.