Liverpool were huge favourites to win the title after opening up a 25-point lead over champions Manchester City before the coronavirus pandemic brought a halt to the season.
There were fears that the campaign would be declared null and void, though it now looks increasingly likely that the season will be able to be completed behind closed doors.
Liverpool need just two more wins - providing City do not slip up - to be confirmed as champions for the first time since 1990, though Henderson has had plenty of recent experience lifting trophies.
Henderson captained Jurgen Klopp's side to Champions League and Fifa Club World Cup glory last year, though similar scenes of jubilation in Liverpool are unlikely given the government's lockdown restrictions.
The Reds skipper admits it will be a surreal experience should Liverpool win the title in an empty ground, telling BBC Radio 5 Live: "Of course it would feel different because if you win any trophy and receive it without any fans there, it would be pretty strange.
"It is still not over. We still have work to do and we still need to perform at a high level right the way until the season finishes because we want to finish as strongly as we can to make sure it is a full season.
"After that, whether we win it or whatever, then [receiving] the trophy and the fans not being there... you just have to deal with it when it comes. Hopefully it does happen. We are still in a very good position.
"It will mean we have won the Premier League and we will all be very happy but then we can look to the future - and whenever fans are allowed back into the stadium, I am sure we will have some sort of celebration together."