Germany has recorded more than 4500 new coronavirus cases in a 24-hour period, marking a jump of nearly 500 compared to the previous day's tally of 4050.
Numbers released on Friday show 4516 new infections have been recorded, compared to 4058 on Thursday.
The country has not recorded such a high number of daily cases since the height of the pandemic in late March and early April, when Germany was counting more than 6000 new cases per day.
Infections then fell off markedly before they began trending upwards again in July.
Major cities have emerged as hotspots in a renewed surge of coronavirus cases across the nation, alarming political leaders and forcing local authorities to launch a new round of restrictions.
The capital Berlin and financial centre Frankfurt became the latest two cities to breach a key threshold measuring the spread of the deadly coronavirus on Thursday.
Chancellor Angela Merkel said she hoped to avoid a second lockdown similar to the one introduced in March as the pandemic took hold.
Merkel plans to hold a conference call on Friday with the mayors of 11 of Germany's largest cities.
At least 314,660 people in Germany have contracted the virus since the pandemic began, and 9589 have died, according to national figures.