Georgina Downer has been chosen as the Liberal Party's candidate for the by-election for the federal seat of Mayo, which was held by her father Alexander Downer from 1984 to 2008.
The party's state director Sascha Meldrum has confirmed Ms Downer was endorsed unopposed on Monday night.
She will now seek to take the Adelaide Hills electorate from the Centre Alliance's Rebekha Sharkie who was forced to resign last week after being caught in the citizenship saga.
Ms Downer, who has spent most of her adult life in Melbourne, regards her return to contest the by-election as something of a homecoming.
"As someone who grew up and spent the first two decades of her life in Mayo, was married in Mayo and whose family have lived in the Adelaide Hills for over a century, I am coming home," she said last week.
She said like so many young South Australians, she went interstate and overseas to seek out job opportunities.
"Now I am coming home to use those experiences and give back to my community," she said.
It will be her second tilt at securing a seat in the federal parliament.
Ahead of the 2016 federal election, Ms Downer sought pre-selection for the Victorian seat of Goldstein but lost to Tim Wilson.
The Speaker of the House of Representatives, Tony Smith, is expected to make a decision this week on when the by-election will be held.
It will most likely be in late June or early July.
Ms Sharkie has apologised to the Mayo community for putting them through another election.
But she said she was proud of what she had achieved since entering the parliament.
"I have much more to do," she said.
Labor and the Greens are also expected to run candidates in Mayo.