Five pedestrians hurt in Melbourne crash

Five pedestrians, including two children, have been hit by a car which lost control following a two-vehicle crash in Melbourne's CBD.

A man and woman, aged in their 30s, were taken to hospital in serious but stable conditions after the crash on the corner of La Trobe and Williams streets on Sunday afternoon.

Two children, one confirmed to be a pre-school- aged girl, were hospitalised for observation and another woman, also aged in her 30s, with rib injuries.

The group was hit by a share car which lost control after being struck by another vehicle, police said.

The Nine Network reports the crash was between an Uber and an RACV van, with the impact throwing the young girl from her pram.

One of the Uber passengers, Nicole Brown, told Nine: "Our car just lost control and it just started spinning and we took out all those people."

The collision is being treated as accidental and anyone who witnessed it has been asked to contact Crime Stoppers on 1800 333 000.