Firefighters contain huge industrial blaze in Sydney

Two people have been taken to hospital after a massive fire at a car repair shop in Sydney's southwest.

More than 100 firefighters were at the industrial site in Auburn on Monday night with crews taking about two hours to contain the blaze.

Fire and Rescue NSW said the fire started about 6pm and became intense, with aerial ladder platforms used to douse the flames from above and drones sent up to aid the effort.

"The roof of the building where the fire started has collapsed however firefighters have protected neighbouring properties including an adjoining timber flooring warehouse and a petrol station," the fire service said in a statement on Monday night.

"It is currently unsafe for firefighters to enter the collapsed building to fully extinguish the blaze."

Two people in the auto shop were taken to hospital for smoke inhalation and burns.

People from surrounding businesses were moved away and residents in the area were warned to stay inside and close windows and doors.

A section of Parramatta Rd was closed in both directions with firefighters expected to work through the night.

Earlier, NSW Police declared an exclusion zone at the site and advised residents within it to leave.